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HPOB

CAT: 0804-HY-19747-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19747-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HPOB is a highly potent and selective inhibitor of HDAC6 with an IC50 of 56 nM. HPOB displays >30 fold less potent against other HDACs. HPOB enhances the effectiveness of DNA-damaging anticancer agents in transformed cells but not normal cells. HPOB does not block the ubiquitin-binding activity of HDAC6[1].
CAS Number
1429651-50-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/HPOB.html
Concentration
10mM
Purity
99.54
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N(CCO)C1=CC=CC=C1)CC2=CC=C(C(NO)=O)C=C2
Molecular Formula
C17H18N2O4
Molecular Weight
314.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Lee JH et al. Development of a histone deacetylase 6 inhibitor and its biological effects. Proc Natl Acad Sci U S A. 2013 Sep 24;110 (39) :15704-9.|[2]Li ZY et al. HPOB, an HDAC6 inhibitor, attenuates corticosterone-induced injury in rat adrenal pheochromocytoma PC12 cells by inhibiting mitochondrial GR translocation and the intrinsic apoptosis pathway. Neurochem Int. 2016 Oct;99:239-51.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC10; HDAC2; HDAC3; HDAC6; HDAC8

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