Kavalactones Mixture

CAT: 0013-GTR19318667Size: 1 mLDry Ice: NoHazardous: No

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CAT#:0013-GTR19318667Size:1 mL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Kavalactones Mixture, 100 μg each of 13 kava compounds/ mL acetonitrile. Kavalactones are found in Piper methysticum and exert a wide variety of activities in vitro and in vivo, including antinociceptive, anxiolytic, hypnotic, anticonvulsant, and anti-inflammatory effects. Kavalactones shorten sleep latency and decrease awake time in sleep-disturbed rats and effectively treat short-term anxiety in humans. In animals, these compounds also activate Nrf2, a transcription factor protective against aβ-induced neurotoxicity in Alzheimer’s disease and inhibit MPTP-induced loss of DA, tyrosine hydroxylase, and nigral neurons in models of Parkinson’s disease. Additionally, kavalactones modulate Na+, K+, and Ca2+ ion channel signaling as well as chemical and thermal pain nociception.

Purity

≥98%

Storage Conditions

Storage Temp: -20°C

Notes

For research use only.

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Kavalactones Mixture

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