5-Hydroxymethyl-2’-deoxycytidine

• Product Name Alternative:

  5hmdC

• UNSPSC Description:

  5-Hydroxymethyl-2’-deoxycytidine (5hmdC) is an oxidation derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA. 5-Hydroxymethyl-2’-deoxycytidine may serve as a marker of irreversibly damaged cells[1][2].

• Target Antigen:

  Others

• Type:

  Natural Products

• Related Pathways:

  Others

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/5-hydroxymethyl-2-deoxycytidine.html

• Purity:

  99.96

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O[C@H]1C[C@H](N2C(N=C(N)C(CO)=C2)=O)O[C@@H]1CO

• Molecular Weight:

  257.24

• References & Citations:

  [1]Ewelina Zarakowska, et al. Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice. J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1003-1009.|[2]Shuo Liu, et al. Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA. Nucleic Acids Res. 2013 Jul;41(13):6421-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  7226-77-9