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5-Hydroxymethyl-2’-deoxycytidine

CAT: 0804-HY-131394-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131394-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5-Hydroxymethyl-2’-deoxycytidine (5hmdC) is an oxidation derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA. 5-Hydroxymethyl-2’-deoxycytidine may serve as a marker of irreversibly damaged cells[1][2].
CAS Number
7226-77-9
Product Name Alternative
5hmdC
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
DNA/RNA Synthesis; Drug Derivative
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5-hydroxymethyl-2-deoxycytidine.html
Purity
99.96
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O[C@H]1C[C@H](N2C(N=C(N)C(CO)=C2)=O)O[C@@H]1CO
Molecular Formula
C10H15N3O5
Molecular Weight
257.24
Precautions
H302, H315, H319
References & Citations
[1]Ewelina Zarakowska, et al. Oxidation Products of 5-Methylcytosine are Decreased in Senescent Cells and Tissues of Progeroid Mice. J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73 (8) :1003-1009.|[2]Shuo Liu, et al. Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA. Nucleic Acids Res. 2013 Jul;41 (13) :6421-9.|[3]Tang Y, et al., Sensitive and simultaneous determination of 5-methylcytosine and its oxidation products in genomic DNA by chemical derivatization coupled with liquid chromatography-tandem mass spectrometry analysis. Anal Chem. 2015 Mar 17;87 (6) :3445-52.|[4]Zhang HY, et al., The existence of 5-hydroxymethylcytosine and 5-formylcytosine in both DNA and RNA in mammals. Chem Commun (Camb) . 2016 Jan 14;52 (4) :737-40.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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