Oxamic acid

• UNSPSC Description:

  Oxamic acid is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis[1][2][3].

• Target Antigen:

  Apoptosis; Lactate Dehydrogenase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/oxamic-acid.html

• Purity:

  99.98

• Solubility:

  H2O : 100 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  NC(C(O)=O)=O

• Molecular Weight:

  89.05

• References & Citations:

  [1]Xiang J, et al. LDH-A inhibitors as remedies to enhance the anticancer effects of PARP inhibitors in ovarian cancer cells. Aging (Albany NY). 2021 Dec 16;13(24):25920-25930.|[2]Zhai X, et al. Inhibition of LDH-A by oxamate induces G2/M arrest, apoptosis and increases radiosensitivity in nasopharyngeal carcinoma cells. Oncol Rep. 2013 Dec;30(6):2983-91.|[3]Muramatsu H, et al. Targeting lactate dehydrogenase‑A promotes docetaxel‑induced cytotoxicity predominantly in castration‑resistant prostate cancer cells. Oncol Rep. 2019 Jul;42(1):224-230.J Proteome Res. 2023 Nov 13.|Adv Sci (Weinh). 2024 Jul 9:e2406333.|Cell Rep. 2024 Aug 30;43(9):114686.|J Anim Sci Biotechnol. 2024 Jun 11;15(1):86.|J Ginseng Res. 2023 Dec 27.|Redox Biol. 2024 Jun 20:75:103246.|Research Square Preprint. 2023 Sep 15.|Theranostics. 2023 Jul 3;13(11):3856-3871.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  471-47-6