NF110

• Description :

  NF110 is a P2X3 receptor antagonist (Ki = 36 nM) and inactive toward P2Y receptors stably expressed (IC50s > 10 M) . NF110 blocks alphabeta-methylene-ATP-induced currents (IC50 = 527 nM) in rat dorsal root ganglia neurons[1].

• UNSPSC :

  12352005

• Target :

  P2X Receptor

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/nf110.html

• Purity :

  93.6

• Solubility :

  H2O : 40 mg/mL (ultrasonic; warming)

• Smiles :

  O=C(NC1=CC(C(NC2=CC=C(S(=O)(O[Na])=O)C=C2)=O)=CC(C(NC3=CC=C(S(=O)(O[Na])=O)C=C3)=O)=C1)NC4=CC(C(NC5=CC=C(S(=O)(O[Na])=O)C=C5)=O)=CC(C(NC6=CC=C(S(=O)(O[Na])=O)C=C6)=O)=C4

• Molecular Formula :

  C41H28N6Na4O17S4

• Molecular Weight :

  1096.91

• References & Citations :

  [1]Hausmann R, et al. The suramin analog 4,4',4'',4'''- (carbonylbis (imino-5,1,3-benzenetriylbis (carbonylimino) ) ) tetra-kis-benzenesulfonic acid (NF110) potently blocks P2X3 receptors: subtype selectivity is determined by location of sulfonic acid groups. Mol Pharmacol. 2006;69 (6) :2058-2067.|[2]Dhar S, et al. Antitumour activity of suramin analogues in human tumour cell lines and primary cultures of tumour cells from patients. Eur J Cancer. 2000;36 (6) :803-809.|[3]Su L, et al. Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. Sci Rep. 2020;10 (1) :18850. Published 2020 Nov 2.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  P2X3 Receptor

• CAS Number :

  [111150-22-2]