Moexiprilat

CAT: 0804-HY-A0114-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-A0114-01Size:1 mg
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Description
Moexiprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50=2.1 nM) and an active metabolite of the prodrug Moexipril (HY-117281) . It is formed from moexipril in vivo by side chain ester hydrolysis. Moexiprilat (10 nM) prevents the estrone- or angiotensin II-stimulated proliferation of primary neonatal rat cardiac fibroblasts. It reduces mean arterial blood pressure and increases the levels of atrial natriuretic peptide, a marker of hypertension, in ovariectomized mice when administered at a dose of 50 mg/kg per day.
CAS Number
[103775-14-0]
Product Name Alternative
RS 10029
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/moexiprilat.html
Smiles
O=C([C@H]1N(C([C@@H](N[C@H](C(O)=O)CCC2=CC=CC=C2)C)=O)CC3=C(C=C(OC)C(OC)=C3)C1)O
Molecular Formula
C25H30N2O7
Molecular Weight
470.51
References & Citations
[1]Cameron, et al. Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4) . Biochem. Pharmacol. 85 (9), 1297-1305 (2013) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-117281Moexipril
HY-B0378A-01Moexipril (hydrochloride)
HY-117281S1Moexipril-d3
HY-117281S-01Moexipril-d5
HY-B0378AR-01Moexipril (hydrochloride) (Standard)
HY-B0378AS-01Moexipril-d5 (hydrochloride)

Alternative Products

CatalogName
456414-01Moexiprilat
sc-484862Moexiprilat Hydrochloride
sc-218867Moexiprilat-d5
sc-218865Moexiprilat Acyl-β-D-glucuronide, >65%
M4320-26Moexiprilat-d5 (2-[2- (1-Carboxy-3-phenyl-d5-propylamino) -propionyl]-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic Acid)
M4320-25Moexiprilat Hydrate (2-[2- (1-Carboxy-3-phenyl-propylamino) -propionyl]-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic Acid Hydrate)

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