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Diaveridine (Standard)

CAT: 0804-HY-B1902R-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1902R-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Diaveridine (Standard) is the analytical standard of Diaveridine. This product is intended for research and analytical applications. Diaveridine (EGIS-5645) is a dihydrofolate reductase (DHFR) inhibitor with a Ki of 11.5 nM for the wild type DHFR and also an antibacterial agent.
CAS Number
5355-16-8
Product Name Alternative
EGIS-5645 (Standard)
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Antifolate; Bacterial; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Others
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/diaveridine-standard.html
Smiles
NC1=NC=C(CC2=CC=C(OC)C(OC)=C2)C(N)=N1
Molecular Formula
C13H16N4O2
Molecular Weight
260.29
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Sirichaiwat C et al. Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum. J Med Chem 47:345-54 (2004) .|[2]Ono T, et al. The genotoxicity of diaveridine and trimethoprim. Environ Toxicol Pharmacol. 1997 Sep;3 (4) :297-306.|[3]Wang J, et al. Acute, mutagenicity, teratogenicity and subchronic oral toxicity studies of diaveridine in rodents. Environ Toxicol Pharmacol. 2015 Sep;40 (2) :660-70.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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