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(±) 5,6-DHET lactone

CAT: 0804-HY-130229Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-130229Size:1 Each
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Description
5,6-DiHET lactone ((±) 5,6-DiHETrE lactone) is a lactonized form of 5,6-EET and 5,6-DiHET. In solution, 5 (6) -EET degrades into 5 (6) -DiHET and 5 (6) -δ-lactone, which can be converted to 5 (6) -DiHET and quantified by GC-MS.1 5,6-DiHET potently induces vasodilation of isolated canine coronary arterioles, with 41 and 100% inhibition occurring at 0.01 and 100 pM, respectively. It also induces vasodilation in isolated human microvessels and increases intracellular calcium levels in a dose-dependent manner, an effect that can be blocked by the nitric oxide scavenger L-NAME.
CAS Number
213126-92-2
Product Name Alternative
(±) 5,6-DiHETrE lactone
UNSPSC
12352005
Hazard Statement
H225-H350
Target
Drug Derivative
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/racemic-5-6-dhet-lactone.html
Smiles
O=C1CCCC(C(O)C/C=C\C/C=C\C/C=C\CCCCC)O1
Molecular Formula
C20H32O3
Molecular Weight
320.47
Precautions
P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P405-P501
References & Citations
[1]Oltman, et al. Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation. Circ. Res. 83 (9), 932-939 (1998) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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