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RA190

CAT: 0804-HY-100739-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100739-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RA190, a bis-benzylidine piperidon, inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.
CAS Number
1617495-03-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RA190.html
Purity
99.04
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1/C(CN(C([C@@H](N)CC2=CC=CC=C2)=O)C/C1=C/C3=CC=C(Cl)C(Cl)=C3)=C\C4=CC=C(Cl)C(Cl)=C4.[H]Cl
Molecular Formula
C28H23Cl5N2O2
Molecular Weight
596.76
Precautions
H302, H315, H319, H335
References & Citations
[1]Anchoori RK, et al. A bis-benzylidine piperidone targeting proteasome ubiquitin receptor RPN13/ADRM1 as a therapy for cancer. Cancer Cell. 2013 Dec 9;24 (6) :791-805.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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bs-60163C-01RA190 --- Ubiquitin Receptor RPN13/ADRM1 Inhibitor

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