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Bavachalcone

CAT: 0804-HY-N0231-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0231-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bavachalcone is a potent inducer of apoptosis. Bavachalcone exerts anticancer activity by promoting autophagy and apoptosis in HepG2 cells. Bavachalcone acts as an anti-neuroinflammatory and antidepressant through the NF-κB pathway. Bavachalcone inhibits osteoclasts by interfering with ERK and Akt signaling pathways and the expression of c-Fos and NFATc1. Bavachalcone exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro[1][2][3][4].
CAS Number
28448-85-3
Product Name Alternative
Broussochalcone B
UNSPSC
12352005
Target
Akt; Antibiotic; Apoptosis; Autophagy; Bacterial; NF-κB; PERK
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; NF-κB; PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Bavachalcone.html
Purity
99.90
Solubility
DMSO : ≥ 34 mg/mL
Smiles
O=C(C1=CC(C/C=C(C)\C)=C(O)C=C1O)/C=C/C2=CC=C(O)C=C2
Molecular Formula
C20H20O4
Molecular Weight
324.37
References & Citations
[1]Park CK, et al. Bavachalcone inhibits osteoclast differentiation through suppression of NFATc1 induction by RANKL. Biochem Pharmacol. 2008 Jun 1;75 (11) :2175-82.|[2]Choi YH, et al. In vitro BACE-1 inhibitory phenolic components from the seeds of Psoralea corylifolia. Planta Med. 2008 Sep;74 (11) :1405-8.|[3]Song HS, et al. Bavachalcone from Cullen corylifolium induces apoptosis and autophagy in HepG2 cells. Phytomedicine. 2018 Feb 1;40:37-47.|[4]Wu X, et al. Upregulation of A20 and TAX1BP1 contributes to the anti-neuroinflammatory and antidepressant effects of bavachalcone. Int Immunopharmacol. 2023 Sep;122:110552.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
TB0767-0050Bavachalcone

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