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Fluzoparib

CAT: 0804-HY-114778-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114778-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fluzoparib (SHR3162) is a potent and orally active PARP1 inhibitor (IC50=1.46±0.72 nM, a cell-free enzymatic assay) with superior antitumor activity. Fluzoparib selectively inhibits the proliferation of homologous recombination repair (HR) -deficient cells, and sensitizes both HR-deficient and HR-proficient cells to cytotoxic agents. Fluzoparib exhibits good pharmacokinetic properties in vivo and can be used for BRCA1/2-mutant relapsed ovarian cancer research[1].
CAS Number
1358715-18-0
Product Name Alternative
SHR3162; Fuzuloparib
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fluzoparib.html
Purity
99.96
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NN=C(CC2=CC=C(F)C(C(N3CC4=NC(C(F)(F)F)=NN4CC3)=O)=C2)C5=C1C=CC=C5
Molecular Formula
C22H16F4N6O2
Molecular Weight
472.40
Precautions
H302, H315, H319
References & Citations
[1]Lei Wang, et al. Pharmacologic characterization of fluzoparib, a novel poly (ADP-ribose) polymerase inhibitor undergoing clinical trials. Cancer Sci. 2019 Mar;110 (3) :1064-1075.|[2]Huiping Li, et al. Phase I dose-escalation and expansion study of PARP inhibitor, fluzoparib (SHR3162), in patients with advanced solid tumors. Chin J Cancer Res. 2020 Jun;32 (3) :370-382.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
PARP1

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