Products for Research Use Only
RegisterLogin

Codrituzumab

CAT: 0804-HY-P99013-01Size: 1 mgDry Ice: YesHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-P99013-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Codrituzumab (GC33) is a humanized monoclonal antibody targeting human GPC3 (glypican-3), with high affinity (Kd of 0.673 nM) . GPC3 is an oncofetal protein expressed on the cell surface of hepatocellular carcinoma (HCC) . Codrituzumab induces antibody-dependent cellular cytotoxicity (ADCC) and inhibits tumor growth[1][2][3][4].
CAS Number
1365267-33-9
Product Name Alternative
GC33; RO5137382
UNSPSC
12352203
Target
Glycoprotein VI
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/codrituzumab.html
Purity
99.07
Solubility
H2O
Smiles
[Codrituzumab]
Molecular Weight
(145.58 kDa)
References & Citations
[1]Mika Endo, et al. Abstract 2747: Anti-glypican-3 monoclonal antibody (codrituzumab/GC33/RO5137382) treatment enhances tumor infiltration of PD-L1-positive macrophages, and combination therapy with anti-PD-L1 monoclonal antibody promotes antitumor effects. Cancer Res (2018) 78 (13_Supplement) : 2747.|[2]Carrasquillo JA, et al. I-124 codrituzumab imaging and biodistribution in patients with hepatocellular carcinoma. EJNMMI Res. 2018 Mar 5;8 (1) :20.|[3]Chen G, et al. Combining expression of GPC3 in tumors and CD16 on NK cells from peripheral blood to identify patients responding to codrituzumab. Oncotarget. 2018 Jan 2;9 (12) :10436-10444.|[4]Abou-Alfa GK, et al. Randomized phase II placebo controlled study of codrituzumab in previously treated patients with advanced hepatocellular carcinoma. J Hepatol. 2016 Aug;65 (2) :289-95.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2

Alternative Products

CatalogName
E40YR1311Codrituzumab
GTR18333597-01Codrituzumab Antibody
C00978-01Codrituzumab-MMAE
591761Codrituzumab (GPC3)
HW310016-01Research Grade Codrituzumab
DW310018Codrituzumab ELISA Kit
E55B0617Codrituzumab (Reference antibody)
DHE84699Codrituzumab-MMAE (ADC)
KBI1240KRIBIOLISA™ Codrituzumab ELISA

Popular Products