Gestrinone

CAT: 0804-HY-101405-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-101405-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Gestrinone (R2323) is a synthetic steroid hormone used to treat endometriosis. It inhibits leiomyoma cells with an IC50 of 43.67 μM. Gestrinone is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

CAS Number

16320-04-0

Product Name Alternative

R 2323

UNSPSC

12352211

Hazard Statement

H361

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Gestrinone.html

Purity

99.76

Solubility

DMSO : ≥ 50 mg/mL|H2O : < 0.1 mg/mL

Smiles

C#C[C@]1(O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CCC4=C3C=C[C@]12CC)=O

Molecular Formula

C21H24O2

Molecular Weight

308.41

Precautions

H361

References & Citations

[1]Tamaya T, et al. Gestrinone (R2323) binding to steroid receptors in human uterine endometrial cytosol. Acta Obstet Gynecol Scand. 1986;65 (5) :439-41.|[2]Zhu Y, et al. Gestrinone inhibits growth of human uterine leiomyoma may relate to activity regulation of ERα, Src and P38 MAPK. Biomed Pharmacother. 2012 Dec;66 (8) :569-77.|[3]Snyder BW, et al. Studies on the mechanism of action of danazol and gestrinone (R2323) in the rat: evidence for a masked estrogen component. Fertil Steril. 1989 Apr;51 (4) :705-10.|[4]Dowsett M, et al. A comparison of the effects of danazol and gestrinone on testosterone binding to sex hormone binding globulin in vitro and in vivo. Clin Endocrinol (Oxf) . 1986 May;24 (5) :555-63.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Alternative Products

Catalog	Name
BA9227-5	Gestrinone
252373	Gestrinone Antibody
G2032-80	Gestrinone discontinued
abx284116	Gestrinone (HRP)
A18011-10	Gestrinone 10mg
A18011-200	Gestrinone 200mg
A18011-50	Gestrinone 50mg
80-1176	Gestrinone-HRP
A18011-100	Gestrinone 100mg
A18011-25	Gestrinone 25mg

Gestrinone

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