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Parthenolide

CAT: 0804-HY-N0141-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0141-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.
CAS Number
20554-84-1
Product Name Alternative
(-) -Parthenolide
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Mitophagy; NF-κB
Type
Natural Products
Related Pathways
Apoptosis; Autophagy; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Parthenolide.html
Purity
99.91
Solubility
DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic)
Smiles
C/C1=C\CC[C@@](C)(O2)[C@H]2[C@@H](OC(C3=C)=O)[C@H]3CC1
Molecular Formula
C15H20O3
Molecular Weight
248.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Nakshatri H, et al. NF-κB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT. Cell Death Dis. 2015 Jan 22;6:e1608.|[2]Zhao X, et al. Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells. J Exp Clin Cancer Res. 2014 Jan 6;33:3.|[3]Barbier-Torres L, et al. Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1. Hepatology. 2015 Oct;62 (4) :1237-48.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
Phase 2
Isoform
NF-κB

Alternative Products

CatalogName
E1KS2341Parthenolide ((-) -Parthenolide)
MBS8506347-01Parthenolide ( (-)-Parthenolide)
MBS385623-01Parthenolide ((-)-Parthenolide)
A10698-50Parthenolide ((-) -Parthenolide) 50mg
N1315-SParthenolide
C08474-100mg(-) -Parthenolide

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