Products for Research Use Only
RegisterLogin

(R) -C12-200

CAT: 0013-GTR19277682-01Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19277682-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
(R) -C12-200, an ionizable cationic lipid (pKa = 7.25) and isomer of C12-200, is utilized in forming lipid nanoparticles (LNPs) for delivering mRNA in vivo. When administered intravenously, LNPs containing (R) -C12-200 with mRNA encoding Cre recombinase result in a smaller increase in the percentage of tdTomato+ hepatocytes, endothelial cells, and Kupffer cells in the liver of Ai14 mice compared to LNPs with (S) -C12-200. Additionally, LNPs with (R) -C12-200 carrying mRNA for purine nucleoside phosphorylase (PNP), an E. coli enzyme that transforms fludarabine phosphate into the cytotoxic agent 2-fluoroadenine, prompt intratumoral PNP expression and diminish tumor volume in a FaDu head and neck squamous cell carcinoma (HNSCC) mouse xenograft model when fludarabine phosphate is co-administered.
Storage Conditions
-20°C
Notes
For research use only.

Related Products

CatalogName
GTR19189808-01C12-200
GTR19241031-01(S) -C12-200
GTR19189762-01C12-Sphingosine
GTR19247982-01Trehalose C12
GTR19277995-01Palmarumycin C12
GTR19216134-01C12-A1
GTR19240927-01C12-TLRa
GTR19232656-01C12-113
GTR19037313-01G3-C12
GTR18904054-01Saposin C12

Alternative Products

CatalogName
BA7862-1C12-200
HY-168776(S) -C12-200
26-6441-02Spacer C12 200 nmol scale
26-6420-02Amino Linker C12 200 nmol scale
DR180366Rhamnolipids C12-C12
BA5980-5G3-C12
C8300-5BODIPY-C12
NKB49118-01PBTTT-c12
VAC-00566-01Saposin C12
TRC-C262770-1MGC12 Ceramide

Popular Products