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22 (S) -hydroxy Cholesterol

CAT: 0013-GTR19277393-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19277393-01Size:1 mg
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Description
22 (S) -hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR) .t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22 (S) -hydroxy Cholesterol also reduces fatty acid synthase (FAS) reporter activity through an LXR response element in the promoter region in COS-1 cells transfected with RXRα and LXRα and decreases the expression of MCP-1 and CCR2 in a mouse model of chronic ethanol consumption.Dietary supplementation of 22 (S) -hydroxy cholesterol (30 mg/kg per day) leads to less body weight gain and lower liver triacylglycerol levels in rats when fed either a regular chow or high-fat diet as well as prevents an increase in plasma triacylglycerol levels resulting from a high-fat diet.
CAS Number
22348-64-7
Smiles
C[C@@]12[C@] ([C@]3 ([C@@] ([C@]4 (C) C (=CC3) C[C@@H] (O) CC4) (CC1) [H]) [H]) (CC[C@@]2 ([C@@H] ([C@H] (CCC (C) C) O) C) [H]) [H]
Molecular Formula
C27H46O2
Molecular Weight
402.65
Storage Conditions
-20°C
Notes
For research use only.

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