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Cevidoplenib

CAT: 0013-GTR19277365-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19277365-01Size:25 mg
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Description
Cevidoplenib is an inhibitor of tyrosine kinase.
CAS Number
1703788-21-9
Smiles
Cc1nn (cc1CN1C[C@H] (O) CO1) -c1ccnc (Nc2ccc3n (C) cc (C (=O) C4CC4) c3c2) n1
Molecular Formula
C25H27N7O3
Molecular Weight
473.53
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Cevidoplenib

Cevidoplenib is an orally available inhibitor of spleen tyrosine kinase (SYK), with potential anti-inflammatory and immunomodulating activities. Upon oral administration, cevidoplenib binds to and inhibits the activity of SYK, blocking Fc receptor and B-cell receptor (BCR)-mediated signaling in inflammatory cells, including macrophages, neutrophils, mast cells, natural killer (NK) cells and B-cells. This leads to the inhibition of the activation of these inflammatory cells, and the related inflammatory responses and tissue damage. SYK, a non-receptor cytoplasmic protein tyrosine kinase widely expressed in hematopoietic cells, plays a key role in Fc receptor and B-cell receptor signaling in inflammatory cells. It is involved in coupling activated immunoreceptors, such as Fc receptors and B-cell receptors, to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis, which are important for allergic and antibody-mediated immune diseases such as immune thrombocytopenia (ITP).

CAS Number1703788-21-9
PubChem CID91754477
IUPAC Namecyclopropyl-[5-[[4-[4-[[(4S)-4-hydroxy-1,2-oxazolidin-2-yl]methyl]-3-methylpyrazol-1-yl]pyrimidin-2-yl]amino]-1-methylindol-3-yl]methanone
Molecular FormulaC25H27N7O3
Molecular Weight473.5
XLogP2
Topological Polar Surface Area110
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Heavy Atom Count35
Formal Charge0
Complexity769
SMILES
CC1=NN(C=C1CN2C[C@@H](CO2)O)C3=NC(=NC=C3)NC4=CC5=C(C=C4)N(C=C5C(=O)C6CC6)C
InChI
InChI=1S/C25H27N7O3/c1-15-17(10-31-12-19(33)14-35-31)11-32(29-15)23-7-8-26-25(28-23)27-18-5-6-22-20(9-18)21(13-30(22)2)24(34)16-3-4-16/h5-9,11,13,16,19,33H,3-4,10,12,14H2,1-2H3,(H,26,27,28)/t19-/m0/s1
InChIKey
YCZUBLQESBVOSH-IBGZPJMESA-N
Chemical Structure
2D Structure
2D structure of Cevidoplenib
CAS: 1703788-21-9
CID: 91754477
Formula: C25H27N7O3
MW: 473.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight473.5
XLogP32
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Exact Mass473.21753775
Monoisotopic Mass473.21753775
Topological Polar Surface Area110 Ų
Heavy Atom Count35
Formal Charge0
Complexity769
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
DTC78821-01Cevidoplenib
E1836-100mgCevidoplenib dimesylate
HY-109082A-01Cevidoplenib (dimesylate)
T9789-01Cevidoplenib dimesylate hydrochloride

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