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ITRI-90

CAT: 0013-GTR19277119-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19277119-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ITRI-90 is an orally active androgen receptor (AR) PROTAC degrader. It effectively degrades full-length AR (AR-FL) and its splice variant AR-V7 proteins via the ubiquitin-proteasome system, thereby inhibiting AR transcriptional activity and its target gene expression. This compound significantly suppresses the proliferation of prostate cancer cells, including those resistant to Enzalutamide, and induces apoptosis. ITRI-90 demonstrates favorable pharmacokinetic properties and exhibits strong antitumor efficacy in vivo, making it valuable for prostate cancer research.
CAS Number
2798907-16-9
Smiles
C (F) (F) (F) C=1N2C (CCC (=N2) N3CCC (CC3) C4=CC=C (OCCCCOCC (N[C@H] (C (=O) N5[C@H] (C (NCC6=CC=C (C=C6) C7=C (C) N=CS7) =O) C[C@H] (O) C5) C (C) (C) C) =O) C=C4) =NN1
Molecular Formula
C45H56F3N9O6S
Molecular Weight
908.06
Storage Conditions
-20°C
Notes
For research use only.

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