SK5527

CAT: 0013-GTR19277112-01Size: 50 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0013-GTR19277112-01Size:50 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

SK5527 is a selective AURKA PROTAC degrader that targets and degrades the AURKA protein, exhibiting a DC50 of 2 nM. It binds to NanoLuc-AURKA with an IC50 of 20 nM. In MYCN-amplified neuroblastoma cells, SK5527 effectively reduces MYCN levels, but its activity is constrained by MDR1-mediated efflux. In vivo, it efficiently lowers AURKA levels. SK5527 serves as a useful tool for neuroblastoma research.

Storage Conditions

-20°C

Notes

For research use only.

SK5527

Popular Products