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GNE-5472

CAT: 0013-GTR19277098-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19277098-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GNE-5472 is a potent dual-function ERαPRRTAC degrader featuring an E3 ligase ligand that acts as a pan-IAP antagonist. By antagonizing cIAP1/2, GNE-5472 activates the non-canonical NF-κB pathway, resulting in a significant upregulation of TNFα expression. It inhibits the proliferation of breast cancer cells and induces apoptosis. GNE-5472 is applicable in breast cancer research.
CAS Number
2417369-99-2
Smiles
C (=C (CC) C1=CC=CC=C1) (C2=CC=C (OCCN (C (CCOCCOCCC (NC3=NC (=C (NC (=O) [C@H]4N (C ([C@@H] (NC ([C@@H] (NC) C) =O) C5CCCCC5) =O) CCC4) S3) C6=CC=CC=C6) =O) =O) C) C=C2) C7=CC=C (O) C=C7
Molecular Formula
C59H73N7O9S
Molecular Weight
1056.33
Storage Conditions
-20°C
Notes
For research use only.

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