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LUF7996

CAT: 0013-GTR19275854-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19275854-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LUF7996 is a CCR2-targeting PROTAC degrader with a DC50 of 2.6 μM, designed to degrade CCR2 effectively. It binds simultaneously to CCR2 and the E3 ligase cereblon, demonstrating sustained and concentration-dependent degradation of CCR2. The compound induces CCR2 degradation via the lysosomal pathway and effectively inhibits monocyte migration in vitro.
CAS Number
3104736-80-0
Smiles
O=C (NCCCCCCNC1=CC=CC=2C (=O) N (C (=O) C12) C3C (=O) NC (=O) CC3) C4=CC=C (OC5=CC=C (Cl) C=C5NS (=O) (=O) C6=CC=C (Cl) C (=C6) C (F) (F) F) C=C4
Molecular Formula
C39H34Cl2F3N5O8S
Molecular Weight
860.68
Storage Conditions
-20°C
Notes
For research use only.

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