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AurAP14

CAT: 0013-GTR19275173-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19275173-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AurAP14 is an Aurora APROTAC degrader with a DC50 of 120 nM. It exhibits notable inhibitory activity against various tumor cell lines, with an IC50 of 0.294 μM in A549 cells and 0.534 μM in MCF-7 cells. AurAP14 induces apoptosis in A549 cells and causes cell cycle arrest in the S and G2/M phases. It demonstrates antitumor efficacy in both A549 and A549/PTR nude mouse xenograft models. AurAP14 is applicable for studying treatments for non-small cell lung cancer (NSCLC) with Aurora A overexpression.
Storage Conditions
-20°C
Notes
For research use only.

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CatalogName
HY-178472AurAP14

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