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NP1192

CAT: 0013-GTR19275137-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19275137-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NP1192 is a potent and selective PROTAC NAT10 degrader that reduces NAT10 protein expression in cancer cells and inhibits ac4C modification. It disrupts the NAT10/HIF-1α/PD-L1 axis, leading to dual suppression of hypoxia-driven glycolysis and immunosuppression, demonstrating significant antitumor efficacy both in vitro and in vivo, and producing synergistic effects when combined with anti-PD-L1 treatment. NP1192 is applicable for research in ovarian cancer, cervical cancer, and glioblastoma.
CAS Number
2966791-41-1
Smiles
N#CC=1C=CC (=CC1) C=2N=C (SC2) N (N=C3CCCC3) CCCCCCC (=O) N4CCN (C=5C=CC=C6C (=O) N (C (=O) C65) C7C (=O) NC (=O) CC7) CC4
Molecular Formula
C39H42N8O5S
Molecular Weight
734.88
Storage Conditions
-20°C
Notes
For research use only.

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