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JPC0661

CAT: 0013-GTR19275053-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19275053-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JPC0661 is a direct and allosteric inhibitor of ΔFOSB. It inhibits the binding of ΔFOSB/JUND and ΔFOSB to DNA with a micromolar IC50 value (9-52 μM), and directly suppresses ΔFOSB-mediated transcription in vitro with an IC50 of 0.82 μM. In vivo, JPC0661 notably reduces the occupancy of ΔFOSB at genomic AP1 sites. JPC0661 disrupts the formation of the ΔFOSB/JUND-DNA complex by binding to a novel groove outside the ΔFOSBDNA binding cleft. JPC0661 is applicable in Alzheimer's disease research.
CAS Number
30479-81-3
Smiles
O=C1N (N=C (N) C1) C2=CC=C (OC=3C=CC=CC3) C (=C2) S (=O) (=O) O
Molecular Formula
C15H13N3O5S
Molecular Weight
347.35
Storage Conditions
-20°C
Notes
For research use only.

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