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KRAS-IN-51

CAT: 0013-GTR19274920-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274920-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KRAS-IN-51 (Compound 597a) is a KRas G12V inhibitor with an IC50 of 2.9 nM for KRas G12V. It has KD values of 17 nM at 20°C and 68 nM at 37°C. KRAS-IN-51 inhibits the phosphorylation of pERK and exhibits antiproliferative activity against SW620 and MIAPaCa-2 cell lines. This compound is applicable for research in colorectal cancer and pancreatic cancer.
CAS Number
3076211-50-9
Smiles
C (#N) C1=C2[C@@]3 (CC=4C (CO3) =C (N=C (OC[C@@]56N (C[C@H] (F) C5) CCC6) N4) N7[C@] (CO) (C) CC7) CC[C@H] (C) C2=CC=C1N
Molecular Formula
C31H39FN6O3
Molecular Weight
562.69
Storage Conditions
-20°C
Notes
For research use only.

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