Products for Research Use Only

4A-BFA-11

CAT: 0013-GTR19274907-01Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19274907-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
4A-BFA-11 is a folate-targeted PEG-MMAE conjugate with specific binding affinity for the folate receptor α (FR-α) (KD= 106.7 nM) . It achieves tumor accumulation by combining PEG-mediated long circulation (EPR effect) with folate receptor targeting. At the tumor site, 4A-BFA-11 undergoes enzymatic cleavage to release the active payload, ensuring precise action. In HeLa mouse models, 4A-BFA-11 effectively delivers, targets, and regulates the release of MMAE within tumor tissues. This compound can be applied in research involving cervical cancer, ovarian cancer, and lung cancer.
Storage Conditions
-20°C
Notes
For research use only.