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KARS-IN-1

CAT: 0013-GTR19274833-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274833-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KARS-IN-1 (152) is an AKR1C3-dependent KARS inhibitor with an AC50 of 9.1 nM for human KARS. It exhibits antiproliferative activity in both H460 (NRF2 pathway-mutant cell line with high AKR1C3 expression) and Hara (NRF2 pathway wild-type cell line with low AKR1C3 expression), with AC50 values of 21 nM and 16 nM, respectively. KARS-IN-1 is applicable in non-small cell lung cancer (NSCLC) research.
CAS Number
2579083-99-9
Smiles
O[C@@H]1CC2 (NC=3C1=CC (F) =CC3) CCN (C (NCC4=CC=C (F) C=C4) =O) CC2
Molecular Formula
C21H23F2N3O2
Molecular Weight
387.43
Storage Conditions
-20°C
Notes
For research use only.

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