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YCH3292

CAT: 0013-GTR19274826-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274826-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YCH3292, a derivative of YCH189, is a potent, selective, and orally active PARP1/2 inhibitor with IC50 values of less than 0.001 nM. YCH3292 enhances the stability of PARP-DNA complexes and exhibits strong antiproliferative activity. It induces DNA double-strand breaks, increases protein levels of γH2AX, P-RPA32, and P-Chk1, and causes tumor cells to undergo S phase or G2/M phase arrest and apoptosis (apoptosis) . In the MC38 xenograft model, YCH3292 effectively suppresses tumor growth.
CAS Number
3049753-10-5
Smiles
O=C1NN=C (C=2C=CC=CC12) CC3=CC=C (F) C (=C3) C (=O) N4CC5=NN=C (C=6OC (=CC6) C7CC7) N5CC4
Molecular Formula
C28H23FN6O3
Molecular Weight
510.53
Storage Conditions
-20°C
Notes
For research use only.

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