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Lck-IN-5

CAT: 0013-GTR19274809-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274809-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lck-IN-5 (example C10) is a potent and selective inhibitor of lymphocyte-specific protein tyrosine kinase (LCK) . It specifically disrupts the interaction between the SH3 domain of LCK and the RK motif of CD3ε, inhibiting LCK recruitment to the T-cell receptor. Lck-IN-5 modulates the activity of CD3ε-containing CAR-T and TRuC-T cells, reduces cytokine secretion, and promotes a central memory-like phenotype associated with enhanced persistence. This compound is applicable in research on autoimmune diseases and graft-versus-host disease.
CAS Number
1356734-45-6
Smiles
FC1=CC=CC (=C1) C2=NN=C (O2) C3CC43CCN (CC5=NC (=NO5) C=6C=CC=C (C6) C) CC4
Molecular Formula
C25H24FN5O2
Molecular Weight
445.5
Storage Conditions
-20°C
Notes
For research use only.

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