Products for Research Use Only
RegisterLogin

GW559090

CAT: 0013-GTR19274788-01Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19274788-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
GW559090 is a selective, competitive, and high-affinity α4 integrin antagonist with a Kd value of 0.19 nM for α4β1. It effectively inhibits the binding of α4β1 to vascular cell adhesion molecule 1 (VCAM-1) and fibronectin, with IC50 values of 7.72 and 8.04 nM, respectively. Additionally, GW559090 suppresses the interaction between α4β7 and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) with an IC50 value of 23 nM. It also inhibits inflammatory infiltration in the eye, repairs the corneal barrier, and restores goblet cell function, making it useful for research into dry eye syndrome associated with Sjögren's syndrome.
CAS Number
278598-52-0
Smiles
C ([C@H] (NC ([C@@H] (NC (COC1=C (C) C=CC=C1) =O) CC (C) C) =O) C (O) =O) C2=CC=C (OC (=O) N3CCC (C (N) =O) CC3) C=C2
Molecular Formula
C31H40N4O8
Molecular Weight
596.68
Storage Conditions
-20°C
Notes
For research use only.

Popular Products