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LH17

CAT: 0013-GTR19274698-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274698-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LH17 is a derivative of Kaempferol and serves as a potent and selective inhibitor of PDE4, with PDE4D2 IC50 at 73 nM and PDE4B2 IC50 at 190 nM. It demonstrates over 136-fold selectivity against other PDE isoenzymes (PDE1B/2A/3A/5A/8A/9A/10A) with IC50s greater than 10000 nM, except for PDE7A1 which has an IC50 of 300 nM. LH17 exhibits unique interactions with the M pocket of PDE4. In vitro and in vivo models show that LH17 has significant antifibrotic effects. This compound is applicable in the study of idiopathic pulmonary fibrosis (IPF) .
Storage Conditions
-20°C
Notes
For research use only.

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