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Betamethasone succinate

CAT: 0013-GTR19274668-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274668-01Size:10 mg
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Description
Betamethasonesuccinate (NSSL-BMS) is a nanoformulation capable of crossing the blood-brain barrier, created by encapsulating Betamethasone hemisuccinate in PEGylated liposomes. By leveraging the enhanced permeability and retention effect of liposomes, Betamethasone succinate effectively delivers potent glucocorticoids to inflammatory sites. It inhibits the secretion of pro-inflammatory cytokines, such as TNF-α and IL-6, while maintaining the levels of the anti-inflammatory cytokine TGF-β. This compound is useful for researching arthritis and cerebral malaria.
CAS Number
27297-42-3
Smiles
C[C@@]12[C@] ([C@]3 ([C@] (F) ([C@@H] (O) C1) [C@]4 (C) C (CC3) =CC (=O) C=C4) [H]) (C[C@H] (C) [C@@]2 (C (COC (CCC (O) =O) =O) =O) O) [H]
Molecular Formula
C26H33FO8
Molecular Weight
492.54
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Betamethasone succinate
CAS Number27297-42-3
PubChem CID3084474
IUPAC Name4-[2-[(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid
Molecular FormulaC26H33FO8
Molecular Weight492.5
XLogP2
Topological Polar Surface Area138
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Heavy Atom Count35
Formal Charge0
Complexity1030
SMILES
C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COC(=O)CCC(=O)O)O)C)O)F)C
InChI
InChI=1S/C26H33FO8/c1-14-10-18-17-5-4-15-11-16(28)8-9-23(15,2)25(17,27)19(29)12-24(18,3)26(14,34)20(30)13-35-22(33)7-6-21(31)32/h8-9,11,14,17-19,29,34H,4-7,10,12-13H2,1-3H3,(H,31,32)/t14-,17-,18-,19-,23-,24-,25-,26-/m0/s1
InChIKey
IEKLVCVEJCEIJD-UYXSPTSISA-N
Chemical Structure
2D Structure
2D structure of Betamethasone succinate
CAS: 27297-42-3
CID: 3084474
Formula: C26H33FO8
MW: 492.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight492.5
XLogP32
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass492.21594617
Monoisotopic Mass492.21594617
Topological Polar Surface Area138 Ų
Heavy Atom Count35
Formal Charge0
Complexity1030
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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