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Neutrophil elastase-IN-7

CAT: 0013-GTR19274655-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274655-01Size:50 mg
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Description
Neutrophil elastase-IN-7 (Compound 12) is a potent inhibitor of human neutrophil elastase (HNE) with an IC50 of 0.54 μM. It also exhibits significant inhibitory activity against various coagulation proteins, with IC50 values of 8.2 μM for thrombin, 12.7 μM for FXa, 1.2 μM for FXIa, and 5.7 μM for FXIIIa. Neutrophil elastase-IN-7 is applicable in the study of inflammation, innate immune responses, and tissue remodeling.
CAS Number
6968-33-8
Smiles
O=S (=O) (O) C1=CC (=C2C=CC (N=NC3=CC=C (C=C3C) C4=CC=C (N=NC=5C=CC=6C (C5O) =C (N) C (=CC6S (=O) (=O) O) S (=O) (=O) O) C (=C4) C) =C (O) C2=C1N) S (=O) (=O) O
Molecular Formula
C34H28N6O14S4
Molecular Weight
872.87
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

6,6'-[(3,3'-Dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[4-amino-5-hydroxy-1,3-naphthalenedisulfonic acid]

Evans blue free acid is a naphthalenesulfonic acid that is the free acid form of the dye Evans blue. The tetrasodium salt is used as a counterstain, especially in fluorescent methods to suppress background autofluorescence. It has a role as a sodium channel blocker and a teratogenic agent. It is a member of azobenzenes, a member of biphenyls, a member of naphthols, a naphthalenesulfonic acid, an aminonaphthalene, a bis(azo) compound and a primary arylamine. It is a conjugate acid of an Evans blue(4-).

CAS Number6968-33-8
PubChem CID3315
IUPAC Name4-amino-6-[[4-[4-[(8-amino-1-hydroxy-5,7-disulfonaphthalen-2-yl)diazenyl]-3-methylphenyl]-2-methylphenyl]diazenyl]-5-hydroxynaphthalene-1,3-disulfonic acid
Molecular FormulaC34H28N6O14S4
Molecular Weight872.9
XLogP4.4
Topological Polar Surface Area393
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count20
Rotatable Bond Count9
Heavy Atom Count58
Formal Charge0
Complexity1840
SMILES
CC1=C(C=CC(=C1)C2=CC(=C(C=C2)N=NC3=C(C4=C(C=C3)C(=CC(=C4N)S(=O)(=O)O)S(=O)(=O)O)O)C)N=NC5=C(C6=C(C=C5)C(=CC(=C6N)S(=O)(=O)O)S(=O)(=O)O)O
InChI
InChI=1S/C34H28N6O14S4/c1-15-11-17(3-7-21(15)37-39-23-9-5-19-25(55(43,44)45)13-27(57(49,50)51)31(35)29(19)33(23)41)18-4-8-22(16(2)12-18)38-40-24-10-6-20-26(56(46,47)48)14-28(58(52,53)54)32(36)30(20)34(24)42/h3-14,41-42H,35-36H2,1-2H3,(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)
InChIKey
COXVTLYNGOIATD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6,6'-[(3,3'-Dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(2,1-diazenediyl)]bis[4-amino-5-hydroxy-1,3-naphthalenedisulfonic acid]
CAS: 6968-33-8
CID: 3315
Formula: C34H28N6O14S4
MW: 872.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight872.9
XLogP34.4
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count20
Rotatable Bond Count9
Exact Mass872.05463428
Monoisotopic Mass872.05463428
Topological Polar Surface Area393 Ų
Heavy Atom Count58
Formal Charge0
Complexity1840
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
sc-365950Neutrophil Elastase (D-7)
sc-365950 PNeutrophil Elastase (D-7) P
AP78434-01Neutrophil elastase
045796Elastase, Neutrophil
C3252-25Neutrophil Elastase Inhibitor
GWB-8F72C4Neutrophil elastase Antibody
GWB-246548Elastase Neutrophil, Antibody
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