Products for Research Use Only

OSU-ERβ-12

CAT: 0013-GTR19274824-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274824-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OSU-ERβ-12 is a selective orally active ERβ agonist capable of crossing the blood-brain barrier, exhibiting an EC50 of 78.3 nM and a Ki of 2.02 nM. It demonstrates over 200-fold selectivity for ERβ over ERα. OSU-ERβ-12 binds strongly to ERβ and reduces the expression of TGF-β-mediated profibrotic genes, thereby aiding in the reduction of liver fibrosis. This compound is useful for studying fibrotic liver diseases, non-alcoholic fatty liver disease (NAFLD), and neuroinflammation.
Storage Conditions
-20°C
Notes
For research use only.