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HSB401

CAT: 0013-GTR19274447-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274447-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HSB401 is an orally active FLT3 inhibitor with IC50 values of 28, 5, 72, and 51 nM for FLT3-WT, FLT3-D835Y, FLT3-ITD-F691L, and FLT3-ITD, respectively. It downregulates the FLT3 signaling pathway, inducing cell cycle arrest and apoptosis. HSB401 does not inhibit c-KIT, which reduces the risk of bone marrow suppression. In the MV4-11 xenograft mouse model, HSB401 significantly suppresses tumor growth and is applicable for research in acute myeloid leukemia (AML) .
CAS Number
3022265-51-3
Smiles
O=C (NCCN (C) C) C1=CC=C (C (F) =C1) C=2N=C3C=CC=4NN=C (C4C3=C5C2CCCC5) C
Molecular Formula
C26H28FN5O
Molecular Weight
445.54
Storage Conditions
-20°C
Notes
For research use only.

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HY-179382HSB401

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