HDAC6-IN-71

CAT: 0013-GTR19274411-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19274411-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

HDAC6-IN-71 (Compound 24) is an HDAC6 inhibitor with IC50 values of 13.68 nM for HDAC6 and 443.12 nM for HDAC1. It effectively suppresses NO production in mouse macrophages with an IC50 of 2.31 μM. By inhibiting the HDAC6-NF-κB signaling pathway, HDAC6-IN-71 reduces the phosphorylation levels of IκB-α and IKK-α/β, and inhibits the expression of downstream inflammatory proteins COX-2 and iNOS. Additionally, it significantly alleviates ulcerative colitis in mice.

CAS Number

3062867-16-4

Smiles

O (C=1C=2C (OC (=O) C1) =CC=CC2) C3=CC=C (/C=C/C (NO) =O) C=C3

Molecular Formula

C18H13NO5

Molecular Weight

323.3

Storage Conditions

-20°C

Notes

For research use only.

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