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PICK1 PDZ-IN-1

CAT: 0013-GTR19274380-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274380-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PICK1 PDZ-IN-1 (Compound 6b) is a selective inhibitor of the protein kinase C binding protein 1 (PICK1 PDZ) domain that can cross the blood-brain barrier, with a Ki value of 27.73 μM. It competitively inhibits the interaction between PICK1 and the GluA2 subunit of AMPA receptors. This compound enhances the survival rate of glutamate-induced HT22 cells and primary cortical neuronal cells while inhibiting ROS production. PICK1 PDZ-IN-1 exhibits neuroprotective effects by reducing the area of cerebral infarction and is applicable in ischemic stroke research.
Storage Conditions
-20°C
Notes
For research use only.

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