Products for Research Use Only

IKKβ-IN-5

CAT: 0013-GTR19274149-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274149-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IKKΒ-IN-5 is an orally active and selective inhibitor of IKKβ, with an IC50 value of 7.5 nM. It directly suppresses IKKβ phosphorylation, thereby mitigating NF-κB-mediated inflammation and survival signaling while enhancing autophagy (autophagy) flux. IKKΒ-IN-5 demonstrates a sixfold selectivity for IKKβ over the homologous kinase IKKα. This compound exhibits potent antiproliferative effects through a dual mechanism of inducing G2/M cell cycle arrest and activating autophagy (autophagy), even under in vitro inflammatory stimulus conditions. IKKΒ-IN-5 shows favorable pharmacokinetic properties in vivo and inhibits tumor growth. It is applicable in research related to colorectal cancer and other potentially inflammation-driven malignancies.
Storage Conditions
-20°C
Notes
For research use only.

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