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PLAGL2-IN-1

CAT: 0013-GTR19274138-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274138-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PLAGL2-IN-1 is an inhibitor of pleomorphic adenoma gene-like 2 (PLAGL2) with a dissociation constant (Kd) of 2.23 μM. This compound suppresses the transcriptional activity of PLAGL2, induces G0/G1 cell cycle arrest and apoptosis, thereby inhibiting the proliferation of hepatocellular carcinoma (HCC) cells. It disrupts extracellular matrix structure and inhibits the PI3K-AKT signaling pathway by reducing AKT phosphorylation levels. Additionally, PLAGL2-IN-1 inhibits tumor growth in HCCLM3 xenograft mouse models and is applicable for research in hepatocellular carcinoma.
CAS Number
3099026-16-8
Smiles
O=C (C1=CC=C (C (=C1) NS (=O) (=O) C=2C=CC=3C=CC=CC3C2) N4CCN (CC4) C (C) C) N5CCN (C (=O) C (Cl) Cl) CC5
Molecular Formula
C30H35Cl2N5O4S
Molecular Weight
632.6
Storage Conditions
-20°C
Notes
For research use only.

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