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LCI133

CAT: 0013-GTR19274129-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274129-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LCI133 is an innovative, highly potent, and selective multi-target kinase inhibitor effective at the nanomolar level. It targets CDK4/6/9 and AURKA/B with IC50 values of 4.7/10.2/4.1 nM and 2.8/10.6 nM, respectively. In MYCN-amplified neuroblastoma BE (2) -C cells, LCI133 induces S/G2 phase arrest and triggers significant apoptosis (apoptosis) . Moreover, LCI133 demonstrates substantial antitumor efficacy in BE (2) -C neuroblastoma xenograft models.
CAS Number
3065284-87-6
Smiles
O=C1C=C (OC2=CC (=CC=C12) C=3C=CC (=CC3) NC=4N=CC=5C=C (C (=O) N (C) C) N (C5N4) C6CCCC6) N7CCOCC7
Molecular Formula
C33H34N6O4
Molecular Weight
578.67
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

CatalogName
HY-179375LCI133

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