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As-CA11

CAT: 0013-GTR19273907-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273907-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
As-CA11 is a thioredoxin reductase (TrxR) inhibitor with an IC50 value of 18.7 nM. It exhibits potent inhibitory activity against HeLa, HepG2, A549, and HL-60 cells, with IC50 values of 0.35, 0.3, 0.43, and 0.28 μM, respectively. As-CA11 induces apoptosis and reactive oxygen species (ROS) production in cancer cells, decreases reduced thioredoxin (Trx) levels, and increases oxidized thioredoxin (Trx) levels. Additionally, As-CA11 demonstrates antitumor activity in a 4T1 tumor-bearing mouse model.
Storage Conditions
-20°C
Notes
For research use only.

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