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VU6052254

CAT: 0013-GTR19273851-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273851-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VU6052254, a derivative of VU0467319, is a selective, potent, orally active positive allosteric modulator of the muscarinic M1 acetylcholine receptor (mAChR1) that can cross the blood-brain barrier, with an EC50 value of 59 nM. It shows no activity on M2-5 receptors (EC50 value greater than 30 μM) . VU6052254 enhances memory and reverses scopolamine-induced cognitive deficits, with a minimum effective dose of 1 mg/kg. This compound is applicable in research on neurological disorders such as Alzheimer's disease.
CAS Number
3035701-02-8
Smiles
O=C1C2=CC=CN=C2CN1CC=3C (F) =CC (=CC3F) C4=CC=C (C5=NN (C=C54) C) C (O) (C) C
Molecular Formula
C25H22F2N4O2
Molecular Weight
448.47
Storage Conditions
-20°C
Notes
For research use only.

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