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FLT3-IN-37

CAT: 0013-GTR19273742-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273742-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FLT3-IN-37 (Compound 6z) is a potent inhibitor of FLT3-ITD, with IC50 values of 1.5 nM for FLT3-ITD and 3.4 nM for TEL-VEGFR2. It exhibits high selectivity for FLT3 wild-type (WT) and c-Kit. The compound inhibits FLT3 phosphorylation and downregulates the expression of p-Akt, p-STAT5, and p-ERK. By causing cell cycle arrest and inducing apoptosis, FLT3-IN-37 demonstrates anti-leukemic activity, making it suitable for research into acute myeloid leukemia (AML) .
Storage Conditions
-20°C
Notes
For research use only.

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