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Aurora A-IN-5

CAT: 0013-GTR19273684-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273684-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aurora A-IN-5 is a potent and highly selective Aurora A inhibitor (IC50= 0.02 μM) with 362 times higher selectivity for Aurora A over Aurora B. This selectivity is due to its unique C−H/π interactions, enhanced hydrophobic contacts, open binding pocket, and tighter protein stacking. Aurora A-IN-5 inhibits Aurora A autophosphorylation, thereby suppressing cancer cell proliferation through G2/M phase arrest, triggering apoptosis, and inhibiting colony formation. It also inhibits tumor growth in MDA-MB-231 xenograft mouse models. Aurora A-IN-5 is applicable for research related to breast cancer, cervical cancer, prostate cancer, and lymphoma.
Storage Conditions
-20°C
Notes
For research use only.

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HY-178343Aurora A-IN-5
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bsm-52018R-Cy5.5Aurora A Recombinant Antibody, Cy5.5 Conjugated
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bs-3049R-APC-Cy5.5Phospho-Aurora B (Thr232) + Aurora C (Thr198) Polyclonal Antibody, APC-Cy5.5 Conjugated
bsm-52018R-PerCP-Cy5.5Aurora A Recombinant Antibody, PerCP-Cy5.5 Conjugated
bsm-52018R-APC-Cy5.5Aurora A Recombinant Antibody, APC-Cy5.5 Conjugated
bs-22695R-PE-Cy5.5Aurora A Polyclonal Antibody, PE-Cy5.5 Conjugated
bs-22286R-Cy5.5Aurora B Polyclonal Antibody, Cy5.5 Conjugated
bs-2749R-APC-Cy5.5Aurora A Polyclonal Antibody, APC-Cy5.5 Conjugated

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