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AHR agonist 10

CAT: 0013-GTR19273913-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273913-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AHR agonist 10 is a potent activator of the AHR pathway (EC50 = 2.01 nM) . It enhances transcription of key downstream target genes of AHR, such as CYP1A1 and CYP1B1, while reducing the expression of CD36 and IL-18, and demonstrates low cytotoxicity in normal cells (> 40 μM) . This compound inhibits the expression of CCL5, CCL20, IL-6, IL-8, S100A9, TLR4, TNF-α, and TNFR1, indicating its effective regulation of inflammatory responses via AHR-dependent signaling. AHR agonist 10 is applicable in psoriasis research.
CAS Number
1191937-43-5
Smiles
C (C) (C) C1=C (O) C=C (/C=C/C2=CC=C (OC) C=C2) C=C1O
Molecular Formula
C18H20O3
Molecular Weight
284.36
Storage Conditions
-20°C
Notes
For research use only.

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