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SIRT2-IN-18

CAT: 0013-GTR19273431-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273431-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SIRT2-IN-18 (Compound 8) is a potent SIRT2 inhibitor, with IC50 values of 5.3 μM for SmSIRT2 and 12.3 μM for hSIRT2. It demonstrates strong anti-schistosomal activity against Schistosoma mansoni strains from Liberia and Puerto Rico, effectively reducing larval and adult worm pair survival, pairing, and egg production, while exhibiting low cytotoxicity to mammalian cells. Additionally, SIRT2-IN-18 enhances histone H3 hyperacetylation and induces apoptosis through cytochrome c mediation.
CAS Number
858032-59-4
Smiles
O=C1N=C2OC3=CC=C4C=CC=CC4=C3C=C2C (=O) N1C=5C=CC=CC5
Molecular Formula
C21H12N2O3
Molecular Weight
340.34
Storage Conditions
-20°C
Notes
For research use only.

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