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Lck-IN-4

CAT: 0013-GTR19273381-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273381-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lck-IN-4 (Compound A-1) is a potent inhibitor of the protein tyrosine kinase Lck, with an IC50 value of 2 nM. It effectively suppresses YAP tyrosine phosphorylation and activity, inducing apoptosis in cholangiocarcinoma (CCA) cells. Additionally, Lck-IN-4 exhibits cytotoxicity against organoids derived from CCA tumors with elevated YAP activity. This compound is applicable in the study of CCA and related cancers.
CAS Number
1326278-38-9
Smiles
CC=1C2=C (N=C (N2C=CN1) [C@H]3CC[C@@H] (CC3) N4CCN (C) CC4) C5=CC (OC) =C (NC (=O) C6=CC=7C (N6C) =CC=CC7OC) C=C5
Molecular Formula
C36H43N7O3
Molecular Weight
621.79
Storage Conditions
-20°C
Notes
For research use only.

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