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D574-0246

CAT: 0013-GTR19273082-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273082-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
D574-0246 is a dual-active inhibitor of OXCT1, targeting the enzyme's keto-dehydrogenase and succinyl-transferase activities. It reduces substrate-specific (LACTB K284) and global protein succinylation in HepG2 cells and lowers the ketolytic activity of OXCT1. The compound decreases the viability of HCC cells with an IC50 of 16.49 μM in PLC cells and 6.656 μM in HepG2 cells. In nude mice with HepG2 xenograft tumors overexpressing OXCT1, D574-0246 demonstrates anti-tumor effects. It is applicable for studies on hepatocellular carcinoma (HCC) .
CAS Number
1269110-12-4
Smiles
O=C (NC1=CC=C2OCOC2=C1) N3CCN (C4=NC (=NC (=C4) C) NC5=CC=C (C=C5) C) CC3
Molecular Formula
C24H26N6O3
Molecular Weight
446.51
Storage Conditions
-20°C
Notes
For research use only.

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