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MIDH1-IN-2

CAT: 0013-GTR19272941-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19272941-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MIDH1-IN-2 is a brain-penetrating inhibitor of isocitrate dehydrogenase 1 (IDH1) . It demonstrates sub-nanomolar potency against IDH1R132H and R132C, with IC50 values of 80.0 and 58.0 nM, respectively, while showing minimal activity against wild-type IDH1/2. Additionally, mIDH1-IN-2 inhibits PDK1 with an IC50 of 0.61 μM and reduces phosphorylation levels of PDH in a dose-dependent manner. The compound also inhibits cell proliferation, induces S-phase arrest, and promotes apoptosis (apoptosis) . mIDH1-IN-2 is applicable in cancer research, including studies on gliomas.
Storage Conditions
-20°C
Notes
For research use only.

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