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NCGC00685960

CAT: 0013-GTR19272929-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19272929-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NCGC00685960 is a potent inhibitor of nicotinamide N-methyltransferase (NNMT) with an IC50 of less than 10 nM. This compound exhibits strong anti-tumor activity, enhances H3K27 trimethylation in ovarian cancer cells, and suppresses α-SMA expression in NNMT-expressing ovarian fibroblasts. It also reduces 1-MNA levels in cancer-associated fibroblasts (CAFs), reverses low SAM and H3K27 methylation, and significantly diminishes collagen contractility. NCGC00685960 is valuable for cancer research.
CAS Number
3091000-99-3
Smiles
O=C1N (C2=C3C (=CC=C2) C=CC (=O) N3) N=C (N1) [C@@H]4CN (CCC5CCCCC5) CCC4.Cl
Molecular Formula
C24H32ClN5O2
Molecular Weight
458
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

CatalogName
HY-175603-01NCGC00685960

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